Journal: PeerJ

Article Title: A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes

doi: 10.7717/peerj.3703

Figure Lengend Snippet: Best fitting scores for the total ODE model described in Fig. 3 , according to the saturation and the dose-dependent hypotheses. This table depicts the fitting score of each metabolic compounds according to the parameter estimation procedure detailed in Material and Methods. The p -value is a score reported by the PottersWheel toolbox in order to evaluate the goodness of the best-fitting set of parameters by taking into account the number of datapoints and the quality of the inferred sets of parameters. Local and global Chi 2 depict more precisely the quality of such sets of parameters. A local score is considered to be valid ( ✓ ) when it is lower than 1 and when its value is located between the errors bars computed by The PottersWheel toolbox at t = 24 h. A global score is valid when all local scores are valid. In other cases, the scores are considered as invalid ✗ and the corresponding hypotheses are rejected.

Article Snippet: The PottersWheel toolbox for Matlab software ( ) was used to sample the family of all possible parameters set θ .

Techniques: Sequencing, Concentration Assay